(1-aminoethylidene)bisphosphonic acid
- Name (1-aminoethylidene)bisphosphonic acid
- CAS 15049-85-1
- Purity 99%
Product Details
High Quality Chinese Factory supply 15049-85-1 (1-aminoethylidene)bisphosphonic acid
- Molecular Formula: C2H9 N O6 P2
- Molecular Weight: 205.044
- Vapor Pressure: 4.16E-13mmHg at 25°C
- Boiling Point: 540.3°Cat760mmHg
- Flash Point: 280.6°C
- PSA： 160.70000
- Density: 1.979g/cm3
- LogP: -0.32550
(1-aminoethylidene)bisphosphonic acid(Cas 15049-85-1) Usage
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General Description |
(1-Aminoethylidene)bisphosphonic acid, also known as alendronic acid, is a bisphosphonate drug that is used to treat osteoporosis and other bone-related diseases. It works by slowing down the breakdown of bones and increasing their density, which helps to prevent fractures and maintain bone strength. The chemical structure of (1-aminoethylidene)bisphosphonic acid features two phosphonate groups and an aminoethylidene group, which give it its ability to bind to calcium in bones and inhibit the activity of osteoclasts, the cells responsible for bone resorption. Additionally, this compound has been shown to reduce the risk of hip, spine, and other fractures in postmenopausal women with osteoporosis, making it an important and widely used medication for the management of bone health. |
InChI:InChI=1/C2H9NO6P2/c1-2(3,10(4,5)6)11(7,8)9/h3H2,1H3,(H2,4,5,6)(H2,7,8,9)
15049-85-1 Relevant articles
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase
Szajnman, Sergio H.,Ravaschino, Esteban L.,Docampo, Roberto,Rodriguez, Juan B.
, p. 4685 - 4690 (2005)
We have investigated the effect of a ser...
Improved synthesis of 1-aminoethylidenediphosphonic acid
Kaabak,Kuz'mina,Khudenko,Tomilov
, p. 1673 - 1674 (2006)
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1-acetamido-ethylidene-1,1-bisphosphonate and preparation method and application thereof
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Paragraph 0035; 0037; 0039-0041, (2017/09/28)
The invention discloses a 1-acetamido-et...
Synthesis of (aminomethylene)bisphosphonic acid derivatives
Prishchenko,Livantsov,Novikova,Livantsova,Petrosyan
, p. 228 - 232 (2016/11/06)
Amino derivatives of methylenebisphospho...
Synthesis of substituted N-formylaminomethylenediphosphonates and their derivatives
Prishchenko, Andrey A.,Livantsov, Mikhail V.,Novikova, Olga P.,Livantsova, Ludmila I.,Averochkin, Gleb M.,Petrosyan, Valery S.
, p. 405 - 410 (2018/01/18)
The convenient methods for the synthesis...
Synthesis of the new types of N-unsubstituted aminomethylenebisorganophosphorus acids and their derivatives
Prishchenko, Andrey A.,Livantsov, Mikhail V.,Novikova, Olga P.,Livantsova, Ludmila I.,Ershov, Ivan S.,Petrosyan, Valery S.
, p. 101 - 105 (2015/03/03)
The interaction of trimethylsilyl esters...
15049-85-1 Process route
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15049-85-1
1-amino-ethane-1,1-diphosphonic acid
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10294-56-1
phosphorous acid
| Conditions | Yield |
|---|---|
|
|
71%
|
-
-
1605320-74-8
tetrakis(trimethylsilyl) (1-aminoethane-1,1-diyl) bisphosphonate
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15049-85-1
1-amino-ethane-1,1-diphosphonic acid
| Conditions | Yield |
|---|---|
|
With
methanol;
In
diethyl ether;
Reflux;
|
98%
|
|
With
methanol;
In
diethyl ether;
at 10 - 50 ℃;
Inert atmosphere;
|
98%
|
|
With
methanol;
In
diethyl ether;
at 10 ℃;
Heating;
|
96%
|
|
With
methanol;
In
diethyl ether;
at 10 ℃;
Inert atmosphere;
Reflux;
|
96%
|
|
With
methanol;
at 10 ℃;
Inert atmosphere;
Reflux;
|
96%
|
15049-85-1 Upstream products
-
75-05-8
acetonitrile
-
762-04-9
phosphonic acid diethyl ester
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60-35-5
acetamide
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1605320-74-8
tetrakis(trimethylsilyl) (1-aminoethane-1,1-diyl) bisphosphonate
15049-85-1 Downstream products
-
13598-36-2
phosphonic Acid
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